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・ Carboxylic acid
・ Carboxymethyl cellulose
・ Carboxymethylenebutenolidase
・ Carboxymethylhydantoinase
・ Carboxymethyloxysuccinate lyase
・ Carboxynorspermidine decarboxylase
・ Carboxynorspermidine synthase
・ Carboxypenicillin
・ Carboxypeptidase
・ Carboxypeptidase A
・ Carboxypeptidase A inhibitor
・ Carboxypeptidase A1
・ Carboxypeptidase A2
・ Carboxypeptidase A6
・ Carboxypeptidase B
Carboxypeptidase B2
・ Carboxypeptidase C
・ Carboxypeptidase D
・ Carboxypeptidase D (disambiguation)
・ Carboxypeptidase E
・ Carboxypeptidase G
・ Carboxypeptidase M
・ Carboxypeptidase P
・ Carboxypeptidase T
・ Carboxypeptidase Taq
・ Carboxypeptidase U
・ Carboxysome
・ Carboxytherapy
・ Carboxyvinyl-carboxyphosphonate phosphorylmutase
・ Carboy


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Carboxypeptidase B2 : ウィキペディア英語版
Carboxypeptidase B2

Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene ''CPB2''.
== Function ==

CPB2 is synthesized by the liver〔Kaushansky K, Lichtman M, Beutler E, Kipps T, Prchal J, Seligsohn U. (2010; edition 8: pages 1833-1834 and 2040-2041) ''Williams Hematology''. McGraw-Hill. ISBN 978-0071621519〕 and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1361 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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